SOCS3 Regulates Dectin-2-Induced Inflammation in PBMCs of Diabetic Patients

Abstract The C-type lectin receptors (CLRs) Dectin-1 and Dectin-2 are involved in several innate immune responses expressed mainly dendritic cells, monocytes, macrophages. This study aims to evaluate the expression function of peripheral blood mononuclear cells (PBMCs) isolated from diabetic patients non-diabetic controls. Our results show that was highest monocytes compared with other leukocyte subpopulations. also found be significantly higher T2D positively correlated markers glucose homeostasis, including HOMA-IR HbA1c. Interestingly, SOCS3, a negative regulator inflammation, lower PBMCs patients. Moreover, SOCS3 negatively level. Further analysis inflammatory signaling pathways showed persistent activation Dectin-2-Syk-NFkB pathway instigated by diminished SOCS3. failed induce suppress subsequent siRNA-mediated knockdown displayed similar phenotype when exposed ligands. Altogether, our findings suggest elevated its relationship could abnormal response observed work supported funded Kuwait University Research Grant No. [SL01/21] Foundation for Advancement Sciences (KFAS) grant (RA MoH-2022-002).